Professional Experience
2022- till Associate Professor, Department of Chemistry NIT Patna.
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2014- 2022 Assistant Professor, Department of Chemistry NIT Patna.
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2011-2014 Assistant Professor, Department of Chemistry NIT Agartala,
Education
2006-2011 Ph.D. Organic Synthesis
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2004-2006 M.Sc. Polymer Science
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2001-2004 B.Sc. Chemistry
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Research at glance
Organic Chemistry group
We work on an interdisciplinary approach where synthesized nitrogen-based heterocyclic systems and their related phylogenies are explored for their biofunctional properties and their role in materials-driven research using combinatorial approaches. Specifically, we work with the design, synthesis, and derivitization of various nitrogenous scaffolds (pyrimidines), that are capable of showing activities like anti-neoplastic, anti-microbial agents, or drug-like candidates. We also work on exploring the chelating properties of nitrogenous ligands through metalo-supramolecular studies.
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Graphene group
Our group is also experienced in designing graphene-based hybrid nanomaterial and exploring their roles in environmental remediation, designing biosensors, and nano-centered drug delivery vehicle. We believe the future growth of graphene-based systems is quite new and is less explored when compared to other chemical entities.
Work summary
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Synthesis, structure & biological application of pyrimidine derivatives (RNA nucleobases)
Pyrimidine nucleobases have a wide range of biological activities like anti-cancer, anti-bacterial, anti-fungal, antiviral, anti-inflammatory, anti-histaminic, adenosine receptor antagonist, etc. Our aim is to design and develop novel bioactive molecules which are of high pharmaceutical value. Promotion of economical and environmentally friendly experimental procedures (green chemistry) will be studied for the synthesis of such compounds. The biological and physicochemical properties of these compounds depend on the ability of molecules to form hydrogen bonding and also to participate in p-stacking interactions. The synthetic exploitation of pyrimidine derivatives is of great interest among researchers due to the variety of potential products. With the importance of multi-topic pyrimidine linkers as building blocks for supramolecular architectures and considering their bioactivity; design and synthesis functionalized pyrimidine moieties are a great challenge.
Metallo-supramolecular complexes of N-bases: Materials for advanced application
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Design of new metallo-supramolecular complexes based on N-bases & to develop their applications as smart materials for molecular recognition, host-guest chemistry, molecular magnetism and bioactive molecules are one of the recent research work. The research on metallo-supramolecular complexes is an intensively growing area in crystal engineering, inorganic, coordination, supramolecular and materials chemistry. Recently, it attracts huge attention due to the structural and practical characteristics of metallo-supramolecular complexes such as their structural diversity, microporosity, MOFs, hydrogen bonding, interesting molecular recognition, ion exchange, non-covalent interactions, host-guest, photoluminescent, electrochemical, biological, magnetic and catalytic properties. From our recent studies of self-assembly methods to the single-step synthesis of new coordination complexes [Mn/Fe/Co/Zn/Cd-nitrosopyrimidine-(violuric acid)], where we showed that the four ligand coordination modes commonly observed in metal-violuric acid derivatives (pyrimidine core unit). Our effort is going on for the design of new mono/hetero (di- & tri-) metallo-supramolecular complexes and study their structural, non-covalent interactions and stimulus-responsive behaviour as smart materials to develop their applications in molecular recognition, crystal engineering, biological activity etc.
GR/GO-based N-bases hybrid nano-materials & its sensing application
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Graphene(GR) / Graphene oxide (GO) based hybrid materials have attracted a lot of scientific interest due to their extraordinary properties. Given the colossal consideration motivated by the properties, GR-based materials are now increasingly used in variety of device applications such as an anode material for Li-ion batteries, bio-sensing, photoelectronic, photocatalytic materials, organic photovoltaic cells and organic light emitting diodes etc. The structural or chemical modifications of GR remarkably improve the properties of such device applications. GR and its analogues as biosensor have gain wide popularity in recent years for the detection of such bioactive molecules. The unique properties of GR, such as, large surface-to-volume ratio, unique optical properties, excellent electrical conductivity, remarkably high carrier mobility, high carrier density, high thermal conductivity, high signal-to-noise ratio and extremely high mechanical strength are advantageous for construction of high performance biosensor. Under this head our group is mainly focussed on synthesis, characterization and bio-sensing applications of GR/GO-bases N-bases hybrid nano-materials for the detection of biological/chemical analytes, insects and metal ions. The present project has immense application potential in Public Health/Indian Armed Force, Agriculture & Environmental sciences.